Case one · ApoB
Marta
, 52
Architect, no symptoms, a normal weight and a borderline LDL. Her particle count said she should not wait a year.
Marker
ApoB, mg/dL
Baseline to month 12
132 → 78
Twelve months of ApoB
ApoB · Marta · 12 months
78
mg/dL at month 12, from 132 at baseline
ApoB
Kerno target
ApoB in mg/dL, venous sample at each review. The dashed line is the Kerno target of 80.
Starting point
Architect, no symptoms, normal weight, runs twice a week. Her last annual check flagged LDL at 141 mg/dL as borderline and suggested a recheck in a year.
Month 0
Annual check: LDL 141 mg/dL, recheck in a year.
What we found
ApoB 132 mg/dL, well above the Kerno target of 80. Lp(a) 38 nmol/L, not elevated. A small plaque on the left carotid at ultrasound. Fasting insulin 9.1, normal. The particle count, not the cholesterol, was the problem.
Baseline morning
Carotid ultrasound: one small plaque, left side.
What we changed
Month one: saturated fat cut by half, 15 g of soluble fibre a day. Month three: ApoB down to 118, not enough. Her physician started a low-dose statin with her GP’s agreement. Training unchanged.
Month 3
Low-dose statin added, agreed with her GP.
At 12 months
ApoB 78 mg/dL at month nine, under target for the first time, and still 78 at month twelve. LDL 84. No change in the carotid plaque at the 12-month ultrasound, which is the expected result. She retests every six months.
Month 12
ApoB 78 mg/dL. Plaque unchanged, as expected.
Three markers, before and after
Lipid panel · Marta · month 12
Bar shows lab range, band shows Kerno target
ApoB
Baseline 132
78
mg/dL
In range
LDL-C
Baseline 141
84
mg/dL
In range
Triglycerides
Baseline 118
96
mg/dL
In range
Values at month 12, baseline under each name. All three now sit inside the Kerno target.
Other cases
Deep sleep
Daniel,
47
Nothing in his blood explained the fatigue. The overnight data did.
61
→
84
min per night
↑ Up
VO2 max
Carmen,
58
She did not need to train more. She needed to train differently.
29
→
34
ml/kg/min
↑ Up
Blood pressure
Jorge,
61
The same blood pressure on half the medication. A flat line was the goal.
124
→
123
systolic, mmHg
→ Flat
